‘What’s happened to the movies? All those Katharine Hepburn and Spencer Tracy films about love? When I watch Rita Hayworth or Fred Astaire dance I think, why don’t we have that any more?’

‘So many films now are all about sex and love,’ continues Jake Gyllenhaal, fixing me with his intense blue eyes. ‘But you really don’t see the two of them coming together. I want love and sex in movies to be different than it has been.’

This isn’t idle talk. It’s a key element in Gyllenhaal’s new film, which takes as its departure point the prescription drug that never fails to raise a titter, but has changed so many millions of lives that it even has royal approval: it received a Queen’s Award for Enterprise in 2001.

That drug is Viagra, and the film is Love & Other Drugs. It’s based on the autobiography Hard Sell: The Evolution Of A Viagra Salesman by Jamie Reidy. The book details the author’s experiences working in the cut-throat pharmaceutical industry just as Viagra became the most talked-about pill on the planet. Jamie worked for Pfizer during a period when the company was generating sales of £1 billion a year from its magical new product.

Jake Gyllenhaal has admitted that he doesn’t see himself as being a Hollywood A-lister.

The 29-year-old Love And Other Drugs star insisted that he feels that in his opinion, he’s still got a lot more to achieve before he joins the elite.

Asked about his leading man status, he told Total Film, ‘I don’t see myself like that at all.

‘That’s very result-orientated. I’ve been like that at different times in my career, but at this point I’m not. I think people look at me a little bit like that, but I don’t.

‘I’ve been the lead in a lot of different movies but it’s never been about that. It’s funny. I was at some event for Prince Of Persia and Tom Cruise and Nicolas Cage were there. And there I was standing with them thinking, ‘What the hell am I doing here?” he laughed.

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Updated with some more Love and Other Drugs interviews. Click the thumbnails to go watch the videos.

The Brokeback Mountain stars team again for Love & Other Drugs, one of director Edward Zwick’s rare big-screen forays into the world of relationships and romance that date to 1986’s About Last Night with Rob Lowe and Demi Moore.

The 58-year-old producer/director has also explored these themes as the creator of the TV shows thirtysomething (1987-91) and Once and Again (1999-2002).

In Zwick’s new dramedy, opening Wednesday, Gyllenhaal, 29, plays Jamie Randall, a slick pharmaceutical salesman peddling the likes of Zoloft and Viagra, who spurns his womanizing ways when he falls for Maggie (Hathaway), a young artist with early-onset Parkinson’s as well as major commitment issues.

“It was an intimate movie, obviously, and one that really depended on getting to know each other,” Zwick says. However, the two performers came in with a connection both personal and professional.

Gyllenhaal and Hathaway worked only eight days together on 2005’s Brokeback Mountain, which cast the two performers as a married couple, but they had the luxury of a long rehearsal period to perfect some of the key sequences with Zwick, from the heartfelt finale to Jamie’s first panic-inducing moment of saying “I love you” to Maggie.

“The first thing (Zwick) said to me was, ‘I’ve seen you be vulnerable in movies, but can you not be vulnerable?’ I was like, ‘Yeah! I can not be vulnerable!’ That was a big thing,” Gyllenhaal says. “Real actors respond to someone saying, ‘Trust your instinct.’ ”

Avoiding cliché was key for Hathaway, 28. “We were sitting there doing the scene, and we just started to improv. I was asking him if he was OK and if he wanted a glass of water and he did, and I tried to rub his shoulders and that’s when he’s like, ‘Don’t touch me!’ And I was like, ‘All right!’ And that made it into the movie, his reaction and my yelp and the whole thing.”

There was also a lot of collaboration in the film’s frequent love scenes and sequences with the two stars in various states of partial and total undress. Gyllenhaal admits Love & Other Drugs is definitely a racy film, but in a different way from Brokeback Mountain, which featured an on-screen romance between him and Heath Ledger.

“It’s sexy, but in a really good way,” Gyllenhaal says. “When two people are in love, they’re comfortable with each other — naked physically, literally and figuratively — and we wanted to portray that.”

Hathaway says that figuring out how they were going to do “this nudity thing” was one of the first conversations they had with Zwick. “We’ve pretty much seen each other partially naked before. It removed any kind of shyness and modesty about it. It made it very practical, like, ‘Oh, we’ve done this!’ There are no surprises there, nothing to be embarrassed about, so I think we were able to launch into it with confidence.”

Mapping Jamie and Maggie’s sexual relationship was a particularly big part of the movie as they became closer and more intimate, according to Gyllenhaal. “The sex they literally have is primal, the positions and everything. That’s Annie’s idea.”

He laughs. “It’s funny that I never think about these things. When you make a movie, it’s just this thing you’re doing among a very small group of people, and then you’re talking to people about how you were naked.”

Hathaway says that Gyllenhaal went out of his way to make sure she always felt comfortable on the set. “He’s a very strong person, so he likes to give a lot to people, and sometimes I do worry about him giving too much.

“I want to say, ‘I’m good, dude. Take care of yourself. Don’t worry about it.’ That protective instinct is really, really strong within him.”

Zwick sees a competitive streak between them, but in the very best way. “They’re both determined to bring their best game to every scene and every moment. They push each other to do the same,” he says.

Gyllenhaal, however, finds the secret of their chemistry in the sense of shared rhythm between himself and Hathaway. “We’re both incredibly musical, so all the rhythms in the movie — be they comedic, dramatic, sexual, whatever — we really feed off of each other really well,” he says.

“I don’t think another two people could have had the same thing, or me with someone else or her with someone else. We have something very special, I think, and I cherish that.”

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