As Anne Hathaway tells Jake Gyllenhaal in “Love & Other Drugs” after he rebounds from a thrashing with an invite for coffee: “Oh, you’re good.” And he is.

When the actor gets on the phone from New York at nearly 6 p.m. on a recent Saturday he reveals, “I just want you to know you’re the last interview of the day. We saved the best for last.”

If he’s exhausted from answering the same half-dozen questions on a loop for the past eight hours, he doesn’t betray it. Besides, who else would inquire about the ink?

Asked about the fake Steelers tattoo he unveiled on “Jimmy Kimmel Live” in December, he says, “You know my devotion then. You know my deep devotion to Pittsburgh.”

As for that team logo on his lower back, he playfully asks, “What do you mean? That’s a real tattoo,” but of course it will be covered up in any future movies. And then he lets the cheeky ruse drop and volunteers, “I really legitimately had a wonderful time when I was in Pittsburgh.”

Pressed about some favorite haunts, he says, “Oh, gosh. Let’s see, I went to so many places. I like to eat. I ate my way around. I ate everywhere. I wish I could remember the names of everything.”

Without any prompting, he recalls, “I loved Dish — the restaurant Dish. I did love the pancakes at Pamela’s, I’d have to say, which is probably the go-to. 21st Street Coffee. There was a Greek place that was right where I lived [in Squirrel Hill], I don’t remember the name.”

Mr. Gyllenhaal, who shot the Ed Zwick film from mid-September to late November 2009, says, “I was surprised at how much I loved all the food and actually how much I loved Pittsburgh. … I loved the change of seasons there, and I loved the people there and I had a great time. I would love to make another movie in Pittsburgh.”

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Jake Gyllenhaal and Anne Hathaway team up—and majorly get it on—for the first time since Brokeback Mountain in their new rom-com Love and Other Drugs (which we can’t stop raving about).

“It’s different because this story is about us,” Jake told us on the carpet for his premiere at the AFI Fest presented by Audi. “The other story was about how we were not into each other.”

And Gyllenhaal is hoping his chemistry with Hathaway in this flick will set the horny record straight. Way straight:

“I would hope that this could clear the air that it was acting,” J.G. said referring to his homolicious role in Brokeback with late BFF Heath Ledger.

“[Anne and I] have sex like 16 or 17 times in this one,” laughed Jake to reporters about his and “Annie’s” chemistry (which is real good).

“To be making a movie also that can be easily cliché and work with someone that talented just ups the game,” Gyllenhaal told us about why he had so much fun on this par-tick flick.

“Maybe it’s our experience in movies past or our love for each other as friends, but there’s real stuff going on. That makes it more special than any romantic comedy I’ve seen lately.”

Oh yeah, and the fact that Jake’s hot tush, abs and invitation muscles are on display totally doesn’t hurt either.

Once we saw the flick for a second time and could pay attention to the acting instead of bod, we think J.G. could get his name thrown around the mix during awards season. At least for a Globe!

BTW, we are also way prepared after you guys check this movie out to answer your “can Anne and Jake please be together in real life?” questions in the Bitch-Backs.

Sorry—strictly plutonic there folks.

But, Jake, don’t totally distance yourself from Brokeback. That role and this one equally showcase your amazing talent and yumness.

We’ll take ya either way!

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